Intraperitoneal glucose tolerance test

Loading data

P-values equal or lower to 10^-4 (P < 0.0001) are marked as significant.



Fasted blood glucose concentration	UC Davis	Vti1a^{tm1.1(KOMP)Vlcg}	homozygote		Early adult	BL3599				1.15x10^-3	3.91x10^-7	3.91x10^-7

Vti1a data charts

Fasted blood glucose concentration

Combination tested with the lowest p-value of 3.91x10^-7

Experiments performed

A Intraperitoneal glucose tolerance test (IPGTT) phenotypic assay was performed on 1595 mice. The charts show the results of measuring Fasted blood glucose concentration in 7 female, 8 male mutants compared to 798 female, 782 male controls. The mutants are for the Vti1a^{tm1.1(KOMP)Vlcg} allele.

Associated phenotype

decreased fasting circulating glucose level

Zygosity

homozygote

Testing protocol

Intraperitoneal glucose tolerance test (IPGTT)

Measured value

Fasted blood glucose concentration

Testing environment

Lab conditions and equipment

Life stage

Early adult

Background Strain

involves: C57BL/6NCrl

Phenotyping center

UC Davis

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Fasted blood glucose concentration / Box plot

Fasted blood glucose concentration / Scatter plot

Results of statistical analysis

Genotype P value

3.91x10^-7

Genotype*Female P value

3.91x10^-7

Genotype*Male P value

1.15x10^-3

Classification

Overally significant [level = 1e-04 , pvalue = 3.90744843814517e-07 ]; and with phenotype threshold value 1e-04 - different size as females greater

Summary statistics of all data in the dataset

Statistical method



Batch effect significant	true
Variance significant	true
Genotype*Sex interaction effect p value	3.91x10^-7
Genotype parameter estimate	1.638
Genotype standard error estimate	7.452
Genotype Effect P Value	3.91x10^-7
Sex Parameter Estimate	1.638
Sex Standard Error Estimate	1.240
Sex Effect P Value	3.91x10^-7
Intercept Estimate	118.558
Intercept Estimate Standard Error	1.191
Sex Male KO P Value	3.91x10^-7
Sex Female KO P Value	3.91x10^-7
WT Residuals Normality Tests	1.51x10^-14
KO Residuals Normality Tests	4.88x10^-1