Vti1a | vesicle transport through interaction with t-SNAREs 1A

GeneMGI:1855699Synonyms: 1110014F16Rik, 1110018K19Rik, +2 more

Physiological systems

21 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Growth/size/body region Hearing/vestibular/ear Behavior/neurological Mortality/aging

14 No significant impact

3 Not tested

Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues

Phenotypes

increased vertical activity1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult7.01x10-6 
decreased thigmotaxis2 supporting datasetsVti1atm1.1(KOMP)VlcghomozygoteEarly adult7.23x10-14 
hyperactivity4 supporting datasetsVti1atm1.1(KOMP)VlcghomozygoteEarly adult3.83x10-20 
abnormal epididymis morphology1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal auditory brainstem response1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult3.73x10-6 
decreased body length1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult6.72x10-8 
enlarged epididymis1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
abnormal behavior1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult7.35x10-14 
increased circulating alkaline phosphatase level1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adult1.44x10-8 
preweaning lethality, incomplete penetrance1 supporting datasetVti1atm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Vti1atm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Vti1atm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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