A Hematology phenotypic assay was performed on 938 mice. The charts show the results of measuring Monocyte differential count in 7 female, 8 male mutants compared to 473 female, 450 male controls. The mutants are for the Fbxl8em2(IMPC)Marc allele.
increased monocyte cell number
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P-values equal or lower to 10-4 (P < 0.0001) are marked as significant.
| Monocyte differential count | MARC | Fbxl8em2(IMPC)Marc | homozygote | Early adult | FBXL8_cas9_del4-1 | 8.4x10-8 | 5.83x10-3 | 5.65x10-3 | |
Fbxl8 data charts
Monocyte differential countExperiments performed
Associated phenotype
Zygosity
homozygote
Testing protocol
Measured value
Monocyte differential count
Testing environment
Lab conditions and equipment
Life stage
Early adult
Background Strain
involves: C57BL/6N
Phenotyping center
MARC
* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.
Monocyte differential count / Box plot
Monocyte differential count / Scatter plot
Results of statistical analysis
Genotype P value
5.65x10-3
Genotype*Female P value
5.83x10-3
Genotype*Male P value
8.4x10-8
Classification
Overally insignificant [level = 1e-04 , pvalue = 0.00564730154481663 ]; but with phenotype threshold value 1e-04 - different size as males greater
Summary statistics of all data in the dataset
Statistical method
| Batch effect significant | true |
| Variance significant | true |
| Genotype*Sex interaction effect p value | 5.65x10-3 |
| Genotype parameter estimate | -0.749 |
| Genotype standard error estimate | 0.723 |
| Genotype Effect P Value | 5.65x10-3 |
| Sex Parameter Estimate | -0.749 |
| Sex Standard Error Estimate | 0.258 |
| Sex Effect P Value | 5.65x10-3 |
| Intercept Estimate | 5.276 |
| Intercept Estimate Standard Error | 0.519 |
| Sex Male KO P Value | 5.65x10-3 |
| Sex Female KO P Value | 5.65x10-3 |
| WT Residuals Normality Tests | 2.52x10-4 |
| KO Residuals Normality Tests | 2.16x10-1 |
Statistical analysis API access
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