COVID-19

The ongoing COVID-19 pandemic has highlighted the importance of biological and biomedical research in the fight against disease and its key role in providing treatments and vaccines. At the IMPC, we know and understand how vital it is that the scientific community continues to share resources, knowledge and expertise. This page has been created to outline the resources the IMPC can offer the scientific community for COVID-19 research. You can also read our official statement for an up-to-date status of broader IMPC resources or read our blog post on the role of mouse models in COVID-19 research.

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Publications

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Identification of required host factors for SARS-CoV-2 infection in human cells

Identified genes required for SAR-CoV-2 infection:

• PIK3C3 – View IMPC Data
• VPS35 – View IMPC Data
• ACE2
• CTSL
• RAB7A
• CCDC22
• ATP6AP1
• COMMD3

Daniloski, Z., Jordan, T.X., Wessels, H.-H., Hoagland, D.A., Kasela, S., Legut, M., Maniatis, S., Mimitou, E.P., Lu, L., Geller, E., Danziger, O., Rosenberg, B.R., Phatnani, H., Smibert, P., Lappalainen, T., tenOever, B.R., Sanjana, N.E., Identification of required host factors for SARSCoV-2 infection in human cells, Cell (2020), doi: https://doi.org/10.1016/j.cell.2020.10.030.

Resources from Members

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Multiple IMPC members across the globe are offering their services to aid in the research of COVID-19. To view the full list of members offering their service please view our Consortium Members page.

The IMPC is also a part of the Global Mouse Models for COVID-19 Consortium (GMMCC). A global partnership of mouse genetics, genomics, and functional assessment centres. For more information visit their website.

Available IMPC KO Lines

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This is a curated list of IMPC alleles that can be used for COVID-19 research, including Pub Med articles illustrating their relevance. Please click ‘view data’ to visit our gene pages where you can find information on phenotypes and links for ordering mice, embryonic stem cells, target vectors and tissues (where available).