increased neutrophil cell number

Loading data

P-values equal or lower to 10^-4 (P < 0.0001) are marked as significant.



Neutrophil differential count	ICS	Tti2^{tm1b(KOMP)Wtsi}	heterozygote		Early adult	IP00006016a				5.01x10^-9	1.94x10^-2	1.94x10^-2

Tti2 data charts

Neutrophil differential count

Combination tested with the lowest p-value of 5.01x10^-9

Experiments performed

A Hematology phenotypic assay was performed on 1340 mice. The charts show the results of measuring Neutrophil differential count in 7 female, 10 male mutants compared to 650 female, 673 male controls. The mutants are for the Tti2^{tm1b(KOMP)Wtsi} allele.

Associated phenotype

increased neutrophil cell number

Zygosity

heterozygote

Testing protocol

Hematology

Measured value

Neutrophil differential count

Testing environment

Lab conditions and equipment

Life stage

Early adult

Background Strain

involves: C57BL/6N

Phenotyping center

ICS

* The high throughput nature of the IMPC means that large control sample sizes may accumulate over a long period of time. See the animal welfare guidelines for more information.

Neutrophil differential count / Box plot

Neutrophil differential count / Scatter plot

Results of statistical analysis

Genotype P value

1.94x10^-2

Genotype*Female P value

1.94x10^-2

Genotype*Male P value

5.01x10^-9

Classification

Overally insignificant [level = 1e-04 , pvalue = 0.0193844474827694 ]; but with phenotype threshold value 1e-04 - different size as males greater

Summary statistics of all data in the dataset

Statistical method



Batch effect significant	true
Variance significant	true
Genotype*Sex interaction effect p value	1.94x10^-2
Genotype parameter estimate	-0.174
Genotype standard error estimate	1.826
Genotype Effect P Value	1.94x10^-2
Sex Parameter Estimate	-0.174
Sex Standard Error Estimate	0.422
Sex Effect P Value	1.94x10^-2
Intercept Estimate	5.037
Intercept Estimate Standard Error	1.729
Sex Male KO P Value	1.94x10^-2
Sex Female KO P Value	1.94x10^-2
WT Residuals Normality Tests	4.86x10^-41
KO Residuals Normality Tests	3.12x10^-2