Histopathology data for Top2a
Severity Score:
- 0 = Normal
- 1 = Mild (observation barely perceptible and not believed to have clinical significance)
- 2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical)
- 3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor)
- 4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)
- 0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
- 1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.
| Spinal cord | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
| Brain | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
| Knee joint | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
| Brown adipose tissue | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
| Lymph node | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
| Pancreas | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
| Tongue | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
| Lung | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
| Sciatic nerve | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
| Eye | heterozygote | #1 | N/A | normal | 0 | 0 | N/A | N/A |
