Top2a | topoisomerase (DNA) II alpha

GeneMGI:98790Synonyms: Top-2, DNA Topoisomerase II alpha

Physiological systems

22 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Mortality/aging Renal/urinary system

11 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Top2a^em2(IMPC)Tcp	homozygote	Early adult	N/A ^*
increased mean corpuscular volume	1 supporting dataset	Top2a^em2(IMPC)Tcp	heterozygote	Early adult	8.43x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Top2a^em2(IMPC)Tcp	heterozygote	Early adult	3.7x10^-14
abnormal skin morphology	1 supporting dataset	Top2a^em2(IMPC)Tcp	heterozygote	Late adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Top2a^em2(IMPC)Tcp	heterozygote	Late adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Top2a^em2(IMPC)Tcp	homozygote	E9.5	N/A ^*
small thymus	1 supporting dataset	Top2a^em2(IMPC)Tcp	heterozygote	Late adult	N/A ^*
prenatal lethality prior to heart atrial septation	1 supporting dataset	Top2a^em2(IMPC)Tcp	homozygote	E15.5	N/A ^*
small spleen	1 supporting dataset	Top2a^em2(IMPC)Tcp	heterozygote	Late adult	N/A ^*
increased circulating aspartate transaminase level	1 supporting dataset	Top2a^em2(IMPC)Tcp	heterozygote	Early adult	2.55x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Top2a.

Associated images

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Histopathology

There is no histopathology data found for Top2a.

IMPC related publications

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External links

No external links available for Top2a.

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*Top2a^em2(IMPC)Tcp*	Exon Deletion	‌	mouse
*Top2a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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