Histopathology data for Cdk4

Severity Score:

0 = Normal
1 = Mild (observation barely perceptible and not believed to have clinical significance)
2 = Moderate (observation visible but involves minor proportion of tissue and clinical consequences of observation are most likely subclinical)
3 = Marked (observation clearly visible involves a significant proportion of tissue and is likely to have some clinical manifestations generally expected to be minor)
4 = Severe (observation clearly visible involves a major proportion of tissue and clinical manifestations are likely associated with significant tissue dysfunction or damage)

Significance Score:

0 = Not significant: Interpreted by the histopathologist to be a finding attributable to background strain (e.g. low-incidence hydrocephalus, microphthalmia) or incidental to mutant phenotype (e.g. hair-induced glossitis, focal hyperplasia, mild mononuclear cell infiltrate).
1 = Significant: Interpreted by the histopathologist as a finding not attributable to background strain and not incidental to mutant phenotype.



Epididymis	heterozygote	#1	N/A	normal	0	0	N/A	N/A
Large intestine	heterozygote	#1	N/A	normal	0	0	N/A	N/A
Spleen	heterozygote	#1	Marked erythroid and megakaryocytic hyperplasia	hyperplasia	1	0	distributed chronic	marked EMH (erythroid) and mild Megakaryocytic hyperplasia
Optic II nerve	heterozygote	#1	N/A	normal	0	0	N/A	N/A
Urinary bladder	heterozygote	#1	N/A	normal	0	0	N/A	N/A
Small intestine	heterozygote	#1	N/A	normal	0	0	N/A	N/A
Lymph node	heterozygote	#1	N/A	normal	0	0	N/A	N/A
Spinal cord	heterozygote	#1	N/A	normal	0	0	N/A	N/A
Femur	heterozygote	#1	N/A	normal	0	0	N/A	N/A
Thyroid	heterozygote	#1	N/A	normal	0	0	N/A	N/A