Cdk4 | cyclin dependent kinase 4

GeneMGI:88357Synonyms: p34<PSK-J3>/cdk4, Crk3

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Embryo Growth/size/body region Vision/eye Hematopoietic system Skeleton Mortality/aging Craniofacial

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

50Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



microphthalmia	1 supporting dataset	Cdk4^{tm1b(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
male infertility	1 supporting dataset	Cdk4^{tm1b(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
decreased body length	1 supporting dataset	Cdk4^{tm1b(NCOM)Mfgc}	heterozygote	Early adult	3.33x10^-6
female infertility	1 supporting dataset	Cdk4^{tm1b(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
edema	1 supporting dataset	Cdk4^{tm1b(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
abnormal cranium morphology	1 supporting dataset	Cdk4^{tm1b(NCOM)Mfgc}	heterozygote	Early adult	2.69x10^-5
preweaning lethality, incomplete penetrance	3 supporting datasets	Cdk4^{tm1b(NCOM)Mfgc}	homozygote	Early adult	N/A ^*
abnormal embryo size	1 supporting dataset	Cdk4^{tm1b(NCOM)Mfgc}	homozygote	E15.5	N/A ^*
increased mean corpuscular volume	1 supporting dataset	Cdk4^{tm1b(NCOM)Mfgc}	heterozygote	Early adult	2.34x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cdk4.

Associated images

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Histopathology

There is no histopathology data found for Cdk4.

IMPC related publications

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External links

No external links available for Cdk4.

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*Cdk4^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Cdk4^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Cdk4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Cdk4^{tm1a(NCOM)Mfgc}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Cdk4^{tm1b(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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