Cdk4 | cyclin dependent kinase 4
Physiological systems
19 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Embryo Growth/size/body region Vision/eye Hematopoietic system Skeleton Mortality/aging Craniofacial
10 No significant impact
5 Not tested
Gene metrics:11Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
50Embryo tissues
| microphthalmia | 1 supporting dataset | Cdk4tm1b(NCOM)Mfgc | homozygote | E15.5 | N/A * | ||
| male infertility | 1 supporting dataset | Cdk4tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| decreased body length | 1 supporting dataset | Cdk4tm1b(NCOM)Mfgc | heterozygote | Early adult | 3.33x10-6 | ||
| female infertility | 1 supporting dataset | Cdk4tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| edema | 1 supporting dataset | Cdk4tm1b(NCOM)Mfgc | homozygote | E15.5 | N/A * | ||
| abnormal cranium morphology | 1 supporting dataset | Cdk4tm1b(NCOM)Mfgc | heterozygote | Early adult | 2.69x10-5 | ||
| preweaning lethality, incomplete penetrance | 3 supporting datasets | Cdk4tm1b(NCOM)Mfgc | homozygote | Early adult | N/A * | ||
| abnormal embryo size | 1 supporting dataset | Cdk4tm1b(NCOM)Mfgc | homozygote | E15.5 | N/A * | ||
| increased mean corpuscular volume | 1 supporting dataset | Cdk4tm1b(NCOM)Mfgc | heterozygote | Early adult | 2.34x10-5 |
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Human diseases caused by Cdk4 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Cdk4.
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| Cdk4tm1(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Cdk4tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Cdk4tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Cdk4tm1a(NCOM)Mfgc | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Cdk4tm1b(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | mouse |