Ewsr1 | Ewing sarcoma breakpoint region 1

GeneMGI:99960Synonyms: Ews

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Limbs/digits/tail Hematopoietic system Behavior/neurological Skeleton Mortality/aging

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

51Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



increased circulating alkaline phosphatase level	1 supporting dataset	Ewsr1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.27x10^-5
increased grip strength	1 supporting dataset	Ewsr1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.72x10^-6
edema	1 supporting dataset	Ewsr1^{tm1b(EUCOMM)Wtsi}	homozygote	E15.5	N/A ^*
edema	1 supporting dataset	Ewsr1^{tm1b(EUCOMM)Wtsi}	heterozygote	E15.5	N/A ^*
short tibia	1 supporting dataset	Ewsr1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.8x10^-7
increased leukocyte cell number	1 supporting dataset	Ewsr1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.73x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Ewsr1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
hyperactivity	1 supporting dataset	Ewsr1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.14x10^-6
increased lymphocyte cell number	1 supporting dataset	Ewsr1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.18x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ewsr1.

Associated images

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Histopathology

There is no histopathology data found for Ewsr1.

IMPC related publications

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External links

No external links available for Ewsr1.

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*Ewsr1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Ewsr1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ewsr1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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