Jak3 | Janus kinase 3

GeneMGI:99928

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Immune system Embryo Nervous system Vision/eye Behavior/neurological Mortality/aging

16 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, incomplete penetrance	3 supporting datasets	Jak3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal placenta morphology	1 supporting dataset	Jak3^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
decreased exploration in new environment	1 supporting dataset	Jak3^em1(IMPC)Mbp	heterozygote	Early adult	3.46x10^-6
hyperactivity	2 supporting datasets	Jak3^em1(IMPC)Mbp	heterozygote	Early adult	1.03x10^-11
cataract	1 supporting dataset	Jak3^em1(IMPC)Mbp	heterozygote	Early adult	1.8x10^-5
decreased anxiety-related response	1 supporting dataset	Jak3^em1(IMPC)Mbp	heterozygote	Early adult	6.17x10^-8
no spontaneous movement	1 supporting dataset	Jak3^em1(IMPC)Mbp	heterozygote	E18.5	N/A ^*
abnormal neural tube morphology	1 supporting dataset	Jak3^em1(IMPC)Mbp	heterozygote	E9.5	N/A ^*
enlarged lymph nodes	1 supporting dataset	Jak3^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
decreased thigmotaxis	2 supporting datasets	Jak3^em1(IMPC)Mbp	heterozygote	Early adult	1.25x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Jak3.

Associated images

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Histopathology

There is no histopathology data found for Jak3.

IMPC related publications

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External links

No external links available for Jak3.

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*Jak3^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Jak3^tm1(KOMP)Mbp*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Jak3^{tm456803(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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