Lama1 | laminin, alpha 1

GeneMGI:99892Synonyms: Lama

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal lens morphology	4 supporting datasets	Lama1^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	2.42x10^-8
abnormal retina morphology	1 supporting dataset	Lama1^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	2.13x10^-7
abnormal retina vasculature morphology	1 supporting dataset	Lama1^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	3.22x10^-5
increased startle reflex	1 supporting dataset	Lama1^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	2.19x10^-5
persistence of hyaloid vascular system	1 supporting dataset	Lama1^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	2.54x10^-8
decreased exploration in new environment	1 supporting dataset	Lama1^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	4.79x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Lama1^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.44x10^-10
preweaning lethality, complete penetrance	1 supporting dataset	Lama1^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lama1.

Associated images

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Histopathology

There is no histopathology data found for Lama1.

IMPC related publications

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External links

No external links available for Lama1.

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*Lama1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Lama1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Lama1^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Lama1^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lama1^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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