Chrna7 | cholinergic receptor, nicotinic, alpha polypeptide 7

GeneMGI:99779Synonyms: alpha7 nicotinic receptor, alpha7-nAChR, +2 more

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Skeleton

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating HDL cholesterol level	1 supporting dataset	Chrna7^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.18x10^-8
increased circulating cholesterol level	1 supporting dataset	Chrna7^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.33x10^-6
abnormal bone structure	1 supporting dataset	Chrna7^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.11x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Chrna7.

Associated images

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Histopathology

There is no histopathology data found for Chrna7.

IMPC related publications

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External links

No external links available for Chrna7.

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*Chrna7^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Chrna7^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Chrna7^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Chrna7^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Chrna7^{tm3a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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