Aldh2 | aldehyde dehydrogenase 2, mitochondrial

GeneMGI:99600Synonyms: Ahd-5, Ahd5

Physiological systems

22 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton

15 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



abnormal startle reflex	1 supporting dataset	Aldh2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	8.13x10^-6
increased bone mineral content	1 supporting dataset	Aldh2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.71x10^-7
increased bone mineral density	1 supporting dataset	Aldh2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	4.63x10^-5
decreased erythrocyte cell number	1 supporting dataset	Aldh2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.24x10^-6
decreased circulating cholesterol level	1 supporting dataset	Aldh2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.57x10^-5
decreased T cell number	1 supporting dataset	Aldh2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.81x10^-5
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Aldh2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.68x10^-6
increased lean body mass	1 supporting dataset	Aldh2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.02x10^-7
abnormal lens morphology	1 supporting dataset	Aldh2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	8.22x10^-6
decreased circulating LDL cholesterol level	1 supporting dataset	Aldh2^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	7.67x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Aldh2.

Associated images

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Histopathology

There is no histopathology data found for Aldh2.

IMPC related publications

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External links

No external links available for Aldh2.

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*Aldh2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Aldh2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Aldh2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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