Gcgr | glucagon receptor

GeneMGI:99572Synonyms: GR

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Renal/urinary system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating cholesterol level	1 supporting dataset	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.28x10^-6
decreased fasting circulating glucose level	1 supporting dataset	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.64x10^-5
increased mean corpuscular volume	1 supporting dataset	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.21x10^-7
decreased total body fat amount	2 supporting datasets	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.5x10^-9
improved glucose tolerance	2 supporting datasets	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.71x10^-14
increased kidney weight	2 supporting datasets	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.78x10^-15
decreased circulating insulin level	1 supporting dataset	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	8.15x10^-5
abnormal bone structure	1 supporting dataset	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.73x10^-6
increased lean body mass	2 supporting datasets	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.96x10^-10
increased liver weight	1 supporting dataset	Gcgr^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.29x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gcgr.

Associated images

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Histopathology

There is no histopathology data found for Gcgr.

IMPC related publications

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External links

No external links available for Gcgr.

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*Gcgr^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Gcgr^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Gcgr^{tm406443(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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