Kdm3a | lysine (K)-specific demethylase 3A

GeneMGI:98847Synonyms: Jmjd1a, Jmjd1, +3 more

Physiological systems

20 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system

8 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased anxiety-related response	1 supporting dataset	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	3.14x10^-13
impaired glucose tolerance	1 supporting dataset	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	9.52x10^-6
small kidney	2 supporting datasets	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	2 supporting datasets	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
eye hemorrhage	1 supporting dataset	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	4.25x10^-6
decreased thigmotaxis	2 supporting datasets	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	2.69x10^-11
abnormal behavior	1 supporting dataset	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	2.44x10^-11
decreased prepulse inhibition	3 supporting datasets	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	4.38x10^-7
small spleen	1 supporting dataset	Kdm3a^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Kdm3a.

Associated images

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Histopathology

There is no histopathology data found for Kdm3a.

IMPC related publications

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External links

No external links available for Kdm3a.

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*Kdm3a^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Kdm3a^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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