Tfrc | transferrin receptor

GeneMGI:98822Synonyms: Trfr, TfR1, +6 more

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Immune system Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

7 Not tested

Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased erythrocyte cell number1 supporting datasetTfrcem1(IMPC)HheterozygoteEarly adult6.85x10-13 
decreased hemoglobin content1 supporting datasetTfrcem1(IMPC)HheterozygoteEarly adult1.94x10-5 
increased red blood cell distribution width1 supporting datasetTfrcem1(IMPC)HheterozygoteEarly adult2.97x10-9 
embryonic lethality prior to tooth bud stage1 supporting datasetTfrcem1(IMPC)HhomozygoteE12.5N/A * 
decreased mean corpuscular hemoglobin1 supporting datasetTfrcem1(IMPC)HheterozygoteEarly adult1.47x10-22 
decreased mean corpuscular volume1 supporting datasetTfrcem1(IMPC)HheterozygoteEarly adult1.52x10-25 
decreased mean corpuscular hemoglobin concentration1 supporting datasetTfrcem1(IMPC)HheterozygoteEarly adult7.42x10-5 
abnormal vocalization1 supporting datasetTfrcem1(IMPC)HheterozygoteEarly adult3.06x10-6 
abnormal gait1 supporting datasetTfrcem1(IMPC)HheterozygoteEarly adult3.91x10-5 
increased large unstained cell number1 supporting datasetTfrcem1(IMPC)HheterozygoteEarly adult6.48x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tfrcem1(IMPC)HExon Deletionmouse

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