Tpo | thyroid peroxidase

GeneMGI:98813

Physiological systems

17 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Limbs/digits/tail Hematopoietic system Behavior/neurological Mortality/aging

11 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal startle reflex	1 supporting dataset	Tpo^em1(IMPC)H	homozygote	Early adult	2.55x10^-6
preweaning lethality, incomplete penetrance	1 supporting dataset	Tpo^em1(IMPC)H	homozygote	Early adult	N/A ^*
decreased circulating glucose level	1 supporting dataset	Tpo^em1(IMPC)H	heterozygote	Early adult	2.8x10^-5
increased circulating iron level	1 supporting dataset	Tpo^em1(IMPC)H	homozygote	Early adult	0
abnormal coat/ hair morphology	1 supporting dataset	Tpo^em1(IMPC)H	homozygote	Early adult	1.08x10^-9
impaired righting response	1 supporting dataset	Tpo^em1(IMPC)H	homozygote	Early adult	1.07x10^-7
improved glucose tolerance	1 supporting dataset	Tpo^em1(IMPC)H	heterozygote	Early adult	7.19x10^-5
abnormal hindlimb morphology	1 supporting dataset	Tpo^em1(IMPC)H	homozygote	Early adult	3.85x10^-13
increased circulating alkaline phosphatase level	1 supporting dataset	Tpo^em1(IMPC)H	homozygote	Early adult	9.48x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Tpo^em1(IMPC)H	homozygote	Early adult	1.73x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tpo.

Associated images

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Histopathology

There is no histopathology data found for Tpo.

IMPC related publications

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External links

No external links available for Tpo.

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*Tpo^em1(IMPC)H*	Indel	‌	mouse
*Tpo^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Tpo^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Tpo^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Tpo^{tm43820(L1L2_st1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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