Timp2 | tissue inhibitor of metalloproteinase 2
Physiological systems
22 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Immune system Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Renal/urinary system
15 No significant impact
2 Not tested
Data collections
Gene metrics:8Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| single kidney | 1 supporting dataset | Timp2em1(IMPC)Hmgu | homozygote | Late adult | N/A * | ||
| increased follicular B cell number | 2 supporting datasets | Timp2em1(IMPC)Hmgu | homozygote | Late adult | 2.14x10-5 | ||
| decreased mean corpuscular volume | 1 supporting dataset | Timp2em1(IMPC)Hmgu | homozygote | Late adult | 7.6x10-5 | ||
| abnormal hindlimb morphology | 1 supporting dataset | Timp2em1(IMPC)Hmgu | homozygote | Late adult | 7.44x10-6 | ||
| abnormal startle reflex | 1 supporting dataset | Timp2em1(IMPC)Hmgu | homozygote | Late adult | 1.93x10-5 | ||
| decreased grip strength | 1 supporting dataset | Timp2em1(IMPC)Hmgu | homozygote | Late adult | 1.67x10-5 | ||
| decreased total retina thickness | 1 supporting dataset | Timp2em1(IMPC)Hmgu | homozygote | Early adult | 6.64x10-5 | ||
| decreased bone mineral content | 2 supporting datasets | Timp2em1(IMPC)Hmgu | homozygote | Early adult | 7x10-6 |
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External links
No external links available for Timp2.
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| Timp2em1(IMPC)Hmgu | Exon Deletion | | mouse |
| Timp2tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Timp2tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |