Thbs1 | thrombospondin 1

GeneMGI:98737Synonyms: Thbs-1, TSP-1, +2 more

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Liver/biliary system Respiratory system Skeleton

17 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased bone mineral content	1 supporting dataset	Thbs1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.73x10^-5
abnormal lung morphology	1 supporting dataset	Thbs1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Thbs1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.43x10^-8
abnormal liver morphology	1 supporting dataset	Thbs1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Thbs1.

Associated images

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Histopathology

There is no histopathology data found for Thbs1.

IMPC related publications

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External links

No external links available for Thbs1.

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*Thbs1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Thbs1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

My Genes