Sptan1 | spectrin alpha, non-erythrocytic 1

GeneMGI:98386Synonyms: Spna-2, alpha-fodrin, +3 more

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Homeostasis/metabolism Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging Cardiovascular system Craniofacial Renal/urinary system

13 No significant impact

2 Not tested

Gene metrics:21Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

embryonic growth retardation1 supporting datasetSptan1em1(IMPC)MbphomozygoteE9.5N/A * 
abnormal vitreous body morphology1 supporting datasetSptan1em1(IMPC)MbpheterozygoteEarly adult5.99x10-5 
abnormal neural tube closure1 supporting datasetSptan1em1(IMPC)MbphomozygoteE9.5N/A * 
abnormal neural tube morphology1 supporting datasetSptan1em1(IMPC)MbphomozygoteE9.5N/A * 
decreased body length1 supporting datasetSptan1em1(IMPC)MbpheterozygoteEarly adult3.52x10-7 
abnormal retina vasculature morphology1 supporting datasetSptan1em1(IMPC)MbpheterozygoteEarly adult7.19x10-6 
abnormal placenta morphology1 supporting datasetSptan1em1(IMPC)MbphomozygoteE15.5N/A * 
cataract1 supporting datasetSptan1em1(IMPC)MbpheterozygoteEarly adult6.35x10-5 
abnormal placenta morphology1 supporting datasetSptan1em1(IMPC)MbpheterozygoteE15.5N/A * 
abnormal visceral yolk sac morphology1 supporting datasetSptan1em1(IMPC)MbphomozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sptan1em1(IMPC)MbpExon Deletionmouse
Sptan1tm1aNarlKO first allele (reporter-tagged insertion with conditional potential)ES Cell

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