Sparc | secreted acidic cysteine rich glycoprotein

GeneMGI:98373Synonyms: BM-40, osteonectin

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Growth/size/body region Limbs/digits/tail Vision/eye Skeleton Craniofacial

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased bone mineral density	1 supporting dataset	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	9.32x10^-6
decreased body weight	3 supporting datasets	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.03x10^-5
cataract	2 supporting datasets	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.29x10^-12
increased circulating calcium level	1 supporting dataset	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	3.54x10^-5
increased circulating alanine transaminase level	1 supporting dataset	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	6.32x10^-6
abnormal incisor color	1 supporting dataset	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.12x10^-9
abnormal coat/hair pigmentation	1 supporting dataset	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.66x10^-7
increased circulating creatine kinase level	1 supporting dataset	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.99x10^-6
abnormal lens morphology	2 supporting datasets	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.85x10^-12
abnormal eye morphology	2 supporting datasets	Sparc^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	1.15x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sparc.

Associated images

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Histopathology

There is no histopathology data found for Sparc.

IMPC related publications

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External links

No external links available for Sparc.

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*Sparc^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Sparc^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Sparc^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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