Sox14 | SRY (sex determining region Y)-box 14

Physiological systems

22 / 24 physiological systems tested

15 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Hearing/vestibular/ear Hematopoietic system Cardiovascular system Craniofacial Renal/urinary system Homeostasis/metabolism Nervous system Vision/eye Respiratory system Behavior/neurological

7 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:34Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased thigmotaxis	6 supporting datasets	Sox14^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.43x10^-8
hyperactivity	8 supporting datasets	Sox14^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.12x10^-23
decreased body weight	1 supporting dataset	Sox14^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.11x10^-12
trunk curl	1 supporting dataset	Sox14^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.98x10^-6
abnormal thymus morphology	1 supporting dataset	Sox14^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal vocalization	1 supporting dataset	Sox14^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.52x10^-6
microphthalmia	1 supporting dataset	Sox14^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Sox14^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased startle reflex	1 supporting dataset	Sox14^{em1(IMPC)Ccpcz}	homozygote	Early adult	3x10^-6
small kidney	1 supporting dataset	Sox14^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sox14.

Associated images

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Histopathology

There is no histopathology data found for Sox14.

IMPC related publications

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External links

No external links available for Sox14.

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*Sox14^{em1(IMPC)Ccpcz}*	Indel	‌	mouse
*Sox14^{tm463883(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes