Spi1 | Spi-1 proto-oncogene

GeneMGI:98282Synonyms: Spi-1, Sfpi-1, +6 more

Physiological systems

21 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Hematopoietic system Mortality/aging Cardiovascular system

18 No significant impact

3 Not tested

Gene metrics:4Significant phenotypes
2Associated diseases
Expression examined in:49Adult tissues
25Embryo tissues

Phenotypes

hemorrhage1 supporting datasetSpi1tm2b(EUCOMM)WtsihomozygoteE15.5N/A * 
decreased erythrocyte cell number1 supporting datasetSpi1tm2b(EUCOMM)WtsiheterozygoteEarly adult4.91x10-5 
preweaning lethality, complete penetrance1 supporting datasetSpi1tm2b(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased mean corpuscular volume1 supporting datasetSpi1tm2b(EUCOMM)WtsiheterozygoteEarly adult1.83x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Spi1em1(IMPC)WtsiPoint Mutationmouse
Spi1tm1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)es cell
mouse
Spi1tm199198(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Spi1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Spi1tm1e(KOMP)WtsiTargeted, non-conditional allelees cell
Spi1tm2(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)es cell
Spi1tm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Spi1tm2b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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