Rac1 | Rac family small GTPase 1

GeneMGI:97845Synonyms: D5Ertd559e

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Mortality/aging Renal/urinary system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Rac1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal lymph node morphology	2 supporting datasets	Rac1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Rac1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
hyperactivity	1 supporting dataset	Rac1^em1(IMPC)Mbp	heterozygote	Early adult	1.99x10^-11
enlarged lymph nodes	2 supporting datasets	Rac1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Rac1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Rac1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
microphthalmia	1 supporting dataset	Rac1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Rac1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Rac1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Rac1.

Associated images

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Histopathology

There is no histopathology data found for Rac1.

IMPC related publications

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External links

No external links available for Rac1.

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*Rac1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse

My Genes