Pthlh | parathyroid hormone-like peptide

GeneMGI:97800Synonyms: PTH-related peptide, PTH-like, +4 more

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Skeleton Mortality/aging Craniofacial

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Pthlh^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal cranium morphology	1 supporting dataset	Pthlh^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	2.11x10^-12
increased blood urea nitrogen level	1 supporting dataset	Pthlh^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	6.61x10^-5
abnormal head morphology	1 supporting dataset	Pthlh^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	3.26x10^-19

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pthlh.

Associated images

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Histopathology

There is no histopathology data found for Pthlh.

IMPC related publications

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External links

No external links available for Pthlh.

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*Pthlh^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pthlh^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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