Ppia | peptidylprolyl isomerase A

GeneMGI:97749Synonyms: cyclophilin A, CypA, +2 more

Physiological systems

21 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Vision/eye Hematopoietic system Cardiovascular system Renal/urinary system

12 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal auditory brainstem response	1 supporting dataset	Ppia^em1(IMPC)Mbp	homozygote	Early adult	2.88x10^-6
increased circulating alkaline phosphatase level	1 supporting dataset	Ppia^em1(IMPC)Mbp	homozygote	Early adult	2.32x10^-29
megacolon	1 supporting dataset	Ppia^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased body length	2 supporting datasets	Ppia^em1(IMPC)Mbp	homozygote	Early adult	2.35x10^-6
increased blood urea nitrogen level	1 supporting dataset	Ppia^em1(IMPC)Mbp	homozygote	Early adult	8.55x10^-7
cataract	1 supporting dataset	Ppia^em1(IMPC)Mbp	homozygote	Early adult	7.74x10^-6
abnormal colon morphology	1 supporting dataset	Ppia^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Ppia^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
enlarged spleen	2 supporting datasets	Ppia^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Ppia^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

Rows per page:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Ppia.

Associated images

Loading...

Histopathology

There is no histopathology data found for Ppia.

IMPC related publications

Loading...

External links

No external links available for Ppia.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Ppia^em1(IMPC)Mbp*	Whole-gene deletion	‌	mouse
*Ppia^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Ppia^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

My Genes