Plcg2 | phospholipase C, gamma 2

GeneMGI:97616Synonyms: PLCgamma2, Plcg-2

Physiological systems

13 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Behavior/neurological Skeleton

8 No significant impact

11 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased mature B cell number	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	7.7x10^-8
decreased circulating cholesterol level	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	2.82x10^-11
decreased hematocrit	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	1.04x10^-5
increased IgM level	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	8.87x10^-6
abnormal glucose homeostasis	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	5.94x10^-5
decreased circulating free fatty acids level	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	7.5x10^-7
decreased hemoglobin content	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	1.4x10^-6
decreased IgG3 level	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	3.13x10^-5
decreased erythrocyte cell number	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	4.3x10^-5
thrombocytosis	1 supporting dataset	Plcg2^Ali14	heterozygote	Early adult	3.12x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Plcg2.

Associated images

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Histopathology

There is no histopathology data found for Plcg2.

IMPC related publications

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External links

No external links available for Plcg2.

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*Plcg2^{em1(IMPC)Wtsi}*	Deletion	‌	mouse
*Plcg2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Plcg2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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