Pfn1 | profilin 1

GeneMGI:97549Synonyms: actin binding protein, Pfn

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Pigmentation Integument Growth/size/body region Vision/eye Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:45Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



improved glucose tolerance	1 supporting dataset	Pfn1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.32x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Pfn1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased body weight	3 supporting datasets	Pfn1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.92x10^-9
increased circulating magnesium level	2 supporting datasets	Pfn1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.93x10^-6
decreased circulating fructosamine level	1 supporting dataset	Pfn1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.16x10^-8
increased circulating amylase level	1 supporting dataset	Pfn1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.47x10^-6
abnormal coat/hair pigmentation	1 supporting dataset	Pfn1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.73x10^-7
fused cornea and lens	1 supporting dataset	Pfn1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.87x10^-6
cornea opacity	1 supporting dataset	Pfn1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.82x10^-5
abnormal cornea morphology	1 supporting dataset	Pfn1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.59x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pfn1.

Associated images

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Histopathology

There is no histopathology data found for Pfn1.

IMPC related publications

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External links

No external links available for Pfn1.

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*Pfn1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Pfn1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pfn1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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