Pcsk5 | proprotein convertase subtilisin/kexin type 5

GeneMGI:97515Synonyms: SPC6, PC6, +4 more

Physiological systems

20 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Digestive/alimentary Behavior/neurological Skeleton Cardiovascular system Mortality/aging Craniofacial

9 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:19Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal tail morphology	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	homozygote	E12.5	N/A ^*
abnormal facial morphology	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	homozygote	E18.5	N/A ^*
abnormal embryo size	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	homozygote	E12.5	N/A ^*
abnormal embryo size	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	homozygote	E15.5	N/A ^*
abnormal body wall morphology	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	homozygote	E18.5	N/A ^*
hemorrhage	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	homozygote	E15.5	N/A ^*
abnormal tail morphology	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	homozygote	E18.5	N/A ^*
increased fasting circulating glucose level	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	heterozygote	Early adult	7.79x10^-5
cleft palate	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	homozygote	E18.5	N/A ^*
increased lean body mass	1 supporting dataset	Pcsk5^{tm1b(KOMP)Mbp}	heterozygote	Early adult	8.92x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pcsk5.

Associated images

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Histopathology

There is no histopathology data found for Pcsk5.

IMPC related publications

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External links

No external links available for Pcsk5.

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*Pcsk5^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pcsk5^{tm1b(KOMP)Mbp}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pcsk5^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell

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