Pcsk1 | proprotein convertase subtilisin/kexin type 1

GeneMGI:97511Synonyms: SPC3, prohormone convertase 1/3, +5 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Vision/eye Behavior/neurological Mortality/aging Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



persistence of hyaloid vascular system	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.72x10^-8
abnormal retina blood vessel morphology	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.62x10^-5
decreased locomotor activity	4 supporting datasets	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.85x10^-18
abnormal retina vasculature morphology	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.86x10^-5
preweaning lethality, incomplete penetrance	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal freezing behavior	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.39x10^-5
abnormal vitreous body morphology	1 supporting dataset	Pcsk1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.85x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Pcsk1.

Associated images

Loading...

Histopathology

There is no histopathology data found for Pcsk1.

IMPC related publications

Loading...

External links

No external links available for Pcsk1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Pcsk1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Pcsk1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Pcsk1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Pcsk1^{tm44480(L1L2_st0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes