Nucb1 | nucleobindin 1

GeneMGI:97388Synonyms: MTEST82, B230337F23Rik, +1 more

Physiological systems

20 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system

8 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased bone mineral content	1 supporting dataset	Nucb1^em1(IMPC)Mbp	homozygote	Late adult	2.21x10^-5
decreased anxiety-related response	1 supporting dataset	Nucb1^em1(IMPC)Mbp	homozygote	Early adult	3.91x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Nucb1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
small heart	1 supporting dataset	Nucb1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal liver morphology	1 supporting dataset	Nucb1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
abnormal lymph node morphology	1 supporting dataset	Nucb1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
decreased thigmotaxis	2 supporting datasets	Nucb1^em1(IMPC)Mbp	homozygote	Early adult	7.8x10^-7
increased grip strength	1 supporting dataset	Nucb1^em1(IMPC)Mbp	homozygote	Middle aged adult	7.77x10^-5
abnormal spleen morphology	2 supporting datasets	Nucb1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*
polycystic kidney	1 supporting dataset	Nucb1^em1(IMPC)Mbp	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nucb1.

Associated images

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Histopathology

There is no histopathology data found for Nucb1.

IMPC related publications

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External links

No external links available for Nucb1.

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*Nucb1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Nucb1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Nucb1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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