Ntf5 | neurotrophin 5

GeneMGI:97381Synonyms: NT4/5, 2900040K06Rik, +5 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal locomotor behavior	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.72x10^-7
decreased mean corpuscular volume	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.94x10^-5
prolonged QT interval	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.13x10^-5
tremors	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.4x10^-7
increased circulating cholesterol level	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.11x10^-6
persistence of hyaloid vascular system	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.27x10^-5
increased circulating HDL cholesterol level	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.15x10^-6
prolonged QRS complex duration	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.34x10^-8
female infertility	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased circulating total protein level	1 supporting dataset	Ntf5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.98x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ntf5.

Associated images

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Histopathology

There is no histopathology data found for Ntf5.

IMPC related publications

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External links

No external links available for Ntf5.

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*Ntf5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Ntf5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ntf5^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ntf5^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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