Notch1 | notch 1

GeneMGI:97363Synonyms: Tan1, 9930111A19Rik, +4 more

Physiological systems

19 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Behavior/neurological Skeleton Mortality/aging

16 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

4Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased grip strength	1 supporting dataset	Notch1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.3x10^-5
abnormal vertebrae morphology	1 supporting dataset	Notch1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.26x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Notch1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
increased startle reflex	1 supporting dataset	Notch1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.75x10^-12

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Notch1.

Associated images

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Histopathology

There is no histopathology data found for Notch1.

IMPC related publications

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External links

No external links available for Notch1.

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*Notch1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Notch1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Notch1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Notch1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Notch1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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