Nos3 | nitric oxide synthase 3, endothelial cell

GeneMGI:97362Synonyms: Nos-3, ecNOS, +2 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Growth/size/body region Hematopoietic system Cardiovascular system Renal/urinary system

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:18Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal kidney morphology	2 supporting datasets	Nos3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal lymph node morphology	2 supporting datasets	Nos3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Nos3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
small kidney	2 supporting datasets	Nos3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
decreased circulating phosphate level	1 supporting dataset	Nos3^em1(IMPC)Mbp	homozygote	Early adult	2.85x10^-7
increased heart weight	2 supporting datasets	Nos3^em1(IMPC)Mbp	homozygote	Early adult	7.74x10^-7
enlarged lymph nodes	2 supporting datasets	Nos3^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased eosinophil cell number	1 supporting dataset	Nos3^em1(IMPC)Mbp	homozygote	Early adult	5.7x10^-7
increased basophil cell number	1 supporting dataset	Nos3^em1(IMPC)Mbp	homozygote	Early adult	5.89x10^-5
decreased lymphocyte cell number	1 supporting dataset	Nos3^em1(IMPC)Mbp	homozygote	Early adult	8.15x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nos3.

Associated images

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Histopathology

There is no histopathology data found for Nos3.

IMPC related publications

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External links

No external links available for Nos3.

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*Nos3^em1(IMPC)Mbp*	Inter-exon deletion	‌	mouse
*Nos3^{tm282188(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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