Nefh | neurofilament, heavy polypeptide

GeneMGI:97309Synonyms: NF200, NF-H, +1 more

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system

15 No significant impact

7 Not tested

Gene metrics:2Significant phenotypes
3Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

increased circulating alanine transaminase level1 supporting datasetNefhtm1.1(KOMP)VlcghomozygoteEarly adult6.26x10-5 
decreased mean corpuscular hemoglobin concentration1 supporting datasetNefhtm1.1(KOMP)VlcghomozygoteEarly adult2.54x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Nefhtm1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)es cell
mouse
Nefhtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
mouse
Nefhtm1.1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (post Cre, with no selection cassette)es cell
Nefhtm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Nefhtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Nefhtm1e(EUCOMM)HmguTargeted, non-conditional allelees cell
Nefhtm2a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell

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