Septin2 | septin 2

GeneMGI:97298Synonyms: Nedd5, Sept2

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Immune system Nervous system Vision/eye Hematopoietic system Mortality/aging Cardiovascular system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Septin2^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Septin2^em1(IMPC)Tcp	heterozygote	Early adult	2.78x10^-5
increased monocyte cell number	1 supporting dataset	Septin2^em1(IMPC)Tcp	heterozygote	Early adult	8.09x10^-5
abnormal lens morphology	1 supporting dataset	Septin2^em1(IMPC)Tcp	heterozygote	Early adult	2.84x10^-5
decreased prepulse inhibition	4 supporting datasets	Septin2^em1(IMPC)Tcp	heterozygote	Early adult	3.68x10^-11
abnormal retina blood vessel morphology	1 supporting dataset	Septin2^em1(IMPC)Tcp	heterozygote	Early adult	7.64x10^-5
abnormal retina vasculature morphology	1 supporting dataset	Septin2^em1(IMPC)Tcp	heterozygote	Early adult	3.56x10^-6
cataract	1 supporting dataset	Septin2^em1(IMPC)Tcp	heterozygote	Early adult	3.58x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Septin2.

Associated images

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Histopathology

There is no histopathology data found for Septin2.

IMPC related publications

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External links

No external links available for Septin2.

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*Septin2^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Septin2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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