Casp2 | caspase 2

GeneMGI:97295Synonyms: Ich-1, Nedd2, +1 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Reproductive system Integument Endocrine/exocrine gland Digestive/alimentary Nervous system Vision/eye Behavior/neurological Renal/urinary system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal vitreous body morphology	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	7.3x10^-5
abnormal retina morphology	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	4.73x10^-5
cataract	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	9.23x10^-5
enlarged testis	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased brain size	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal brain morphology	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
increased startle reflex	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	7.68x10^-5
enlarged cecum	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal cecum morphology	1 supporting dataset	Casp2^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Casp2.

Associated images

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Histopathology

There is no histopathology data found for Casp2.

IMPC related publications

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External links

No external links available for Casp2.

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*Casp2^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Casp2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Casp2^{tm291688(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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