Mdh2 | malate dehydrogenase 2, NAD (mitochondrial)

GeneMGI:97050Synonyms: Mdh-2, Mor-1, +1 more

Physiological systems

15 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Embryo Growth/size/body region Nervous system Mortality/aging Cardiovascular system

10 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Mdh2^em1(IMPC)Bay	homozygote	Early adult	N/A ^*
abnormal neural tube morphology	1 supporting dataset	Mdh2^em1(IMPC)Bay	homozygote	E9.5	N/A ^*
abnormal embryo turning	1 supporting dataset	Mdh2^em1(IMPC)Bay	homozygote	E9.5	N/A ^*
abnormal vitelline vasculature morphology	1 supporting dataset	Mdh2^em1(IMPC)Bay	homozygote	E9.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Mdh2^em1(IMPC)Bay	homozygote	E9.5	N/A ^*
abnormal embryo size	1 supporting dataset	Mdh2^em1(IMPC)Bay	homozygote	E9.5	N/A ^*
abnormal neural tube closure	1 supporting dataset	Mdh2^em1(IMPC)Bay	homozygote	E9.5	N/A ^*
abnormal forebrain development	1 supporting dataset	Mdh2^em1(IMPC)Bay	homozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Mdh2^em1(IMPC)Bay	homozygote	E12.5	N/A ^*
abnormal midbrain development	1 supporting dataset	Mdh2^em1(IMPC)Bay	homozygote	E9.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mdh2.

Associated images

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Histopathology

There is no histopathology data found for Mdh2.

IMPC related publications

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External links

No external links available for Mdh2.

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*Mdh2^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Mdh2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Mdh2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Mdh2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mdh2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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