Mep1a | meprin 1 alpha

GeneMGI:96963Synonyms: meprin A alpha-subunit, Mep1, +3 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Skeleton

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased fasting circulating glucose level	1 supporting dataset	Mep1a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	1.7x10^-6
abnormal bone structure	1 supporting dataset	Mep1a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	6.15x10^-6
increased bone mineral content	1 supporting dataset	Mep1a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	5.15x10^-7
decreased total body fat amount	1 supporting dataset	Mep1a^{tm1a(KOMP)Wtsi}	homozygote	Early adult	4.27x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mep1a.

Associated images

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Histopathology

There is no histopathology data found for Mep1a.

IMPC related publications

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External links

No external links available for Mep1a.

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*Mep1a^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Mep1a^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mep1a^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Mep1a^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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