Mag | myelin-associated glycoprotein

GeneMGI:96912Synonyms: Gma, siglec-4a

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Hearing/vestibular/ear Nervous system Hematopoietic system Behavior/neurological

13 No significant impact

6 Not tested

Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

abnormal auditory brainstem response4 supporting datasetsMagtm1.1(KOMP)VlcghomozygoteEarly adult6.67x10-7 
decreased coping response1 supporting datasetMagtm1.1(KOMP)VlcghomozygoteEarly adult2x10-5 
decreased locomotor activity1 supporting datasetMagtm1.1(KOMP)VlcghomozygoteEarly adult6.77x10-5 
abnormal sleep behavior1 supporting datasetMagtm1.1(KOMP)VlcghomozygoteEarly adult3.94x10-6 
convulsive seizures1 supporting datasetMagtm1.1(KOMP)VlcghomozygoteEarly adult3.75x10-15 
decreased leukocyte cell number1 supporting datasetMagtm1.1(KOMP)VlcghomozygoteEarly adult7.62x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Magtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Magtm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse
Magtm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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