M6pr | mannose-6-phosphate receptor, cation dependent

GeneMGI:96904Synonyms: CD-MPR, Mpr46

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Immune system Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased thigmotaxis2 supporting datasetsM6prem1(IMPC)MbphomozygoteEarly adult2.87x10-25 
decreased anxiety-related response1 supporting datasetM6prem1(IMPC)MbphomozygoteEarly adult3.05x10-29 
eye hemorrhage1 supporting datasetM6prem1(IMPC)MbphomozygoteEarly adult4.06x10-5 
abnormal behavior1 supporting datasetM6prem1(IMPC)MbphomozygoteEarly adult2.88x10-25 
small spleen1 supporting datasetM6prem1(IMPC)MbphomozygoteEarly adultN/A * 
decreased locomotor activity1 supporting datasetM6prem1(IMPC)MbphomozygoteEarly adult3.64x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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M6prem1(IMPC)MbpExon Deletionmouse
M6prtm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
M6prtm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
M6prtm42403(L1L2_st2)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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