Lef1 | lymphoid enhancer binding factor 1

GeneMGI:96770Synonyms: Lef-1, lymphoid enhancer factor 1

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Immune system Nervous system Hematopoietic system Craniofacial Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

0Associated diseases

Expression examined in:73Adult tissues

29Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased prepulse inhibition	2 supporting datasets	Lef1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	2.49x10^-6
abnormal craniofacial morphology	1 supporting dataset	Lef1^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Lef1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
increased monocyte cell number	1 supporting dataset	Lef1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	5.7x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lef1.

Associated images

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Histopathology

There is no histopathology data found for Lef1.

IMPC related publications

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External links

No external links available for Lef1.

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*Lef1^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Lef1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Lef1^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell
*Lef1^{tm1.1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	ES Cell
*Lef1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Lef1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Lef1^{tm40347(L1L2_gt1)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes