Ldlr | low density lipoprotein receptor

GeneMGI:96765

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hearing/vestibular/ear Behavior/neurological

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased circulating iron level	1 supporting dataset	Ldlr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	7.69x10^-6
decreased circulating unsaturated transferrin level	1 supporting dataset	Ldlr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.6x10^-6
increased circulating cholesterol level	1 supporting dataset	Ldlr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.11x10^-60
increased circulating HDL cholesterol level	1 supporting dataset	Ldlr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	1.24x10^-19
abnormal auditory brainstem response	1 supporting dataset	Ldlr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	5.74x10^-5
increased grip strength	2 supporting datasets	Ldlr^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	2.16x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ldlr.

Associated images

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Histopathology

There is no histopathology data found for Ldlr.

IMPC related publications

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External links

No external links available for Ldlr.

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*Ldlr^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Ldlr^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Ldlr^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ldlr^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Ldlr^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Ldlr^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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