Krt8 | keratin 8

GeneMGI:96705Synonyms: Card2, Krt-2.8, +7 more

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Nervous system Hematopoietic system Behavior/neurological Mortality/aging

13 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Krt8^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
decreased exploration in new environment	1 supporting dataset	Krt8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.64x10^-5
improved glucose tolerance	2 supporting datasets	Krt8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.37x10^-5
increased neutrophil cell number	1 supporting dataset	Krt8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	5.38x10^-5
increased prepulse inhibition	1 supporting dataset	Krt8^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.71x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Krt8.

Associated images

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Histopathology

There is no histopathology data found for Krt8.

IMPC related publications

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External links

No external links available for Krt8.

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*Krt8^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Krt8^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Krt8^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Krt8^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Krt8^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Krt8^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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