Krt2 | keratin 2

GeneMGI:96699Synonyms: Krt2-17, Krt2-2, +1 more

Physiological systems

21 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Reproductive system Endocrine/exocrine gland Growth/size/body region Behavior/neurological Mortality/aging Renal/urinary system

15 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



enlarged kidney	1 supporting dataset	Krt2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
decreased grip strength	1 supporting dataset	Krt2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	6.13x10^-5
abnormal testis morphology	1 supporting dataset	Krt2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Krt2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Krt2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
polycystic kidney	1 supporting dataset	Krt2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Krt2^{tm1b(KOMP)Wtsi}	heterozygote	Early adult	N/A ^*
preweaning lethality, incomplete penetrance	2 supporting datasets	Krt2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Krt2.

Associated images

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Histopathology

There is no histopathology data found for Krt2.

IMPC related publications

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External links

No external links available for Krt2.

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*Krt2^{tm1a(KOMP)Mbp}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Krt2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Krt2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Krt2^{tm1e(KOMP)Mbp}*	Targeted, non-conditional allele	‌	ES Cell
*Krt2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Krt2^{tm2a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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