Igfbp3 | insulin-like growth factor binding protein 3

GeneMGI:96438Synonyms: IGFBP-3

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Pigmentation Integument Limbs/digits/tail Skeleton Cardiovascular system

12 No significant impact

7 Not tested

Gene metrics:4Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

abnormal coat/hair pigmentation3 supporting datasetsIgfbp3tm1b(KOMP)WtsihomozygoteEarly adult6.16x10-8 
shortened ST segment1 supporting datasetIgfbp3tm1b(KOMP)WtsihomozygoteEarly adult1.78x10-5 
short tibia1 supporting datasetIgfbp3tm1b(KOMP)WtsihomozygoteEarly adult4.04x10-5 
thick ventricular wall2 supporting datasetsIgfbp3tm1b(KOMP)WtsihomozygoteEarly adult3.95x10-8 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Igfbp3tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
mouse
Igfbp3tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Igfbp3tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Igfbp3tm1e(KOMP)WtsiTargeted, non-conditional allelees cell

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