Htr1b | 5-hydroxytryptamine (serotonin) receptor 1B

GeneMGI:96274Synonyms: 5-HT<1B> receptor, 5HT1B receptor, +1 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Adipose tissue Growth/size/body region Behavior/neurological Cardiovascular system Mortality/aging

12 No significant impact

7 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
47Embryo tissues

Phenotypes

increased lean body mass1 supporting datasetHtr1btm1.1(KOMP)VlcgheterozygoteEarly adult8.62x10-6 
decreased grip strength1 supporting datasetHtr1btm1.1(KOMP)VlcgheterozygoteEarly adult8.84x10-5 
decreased total body fat amount1 supporting datasetHtr1btm1.1(KOMP)VlcgheterozygoteEarly adult5.15x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetHtr1btm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
hyperactivity1 supporting datasetHtr1btm1.1(KOMP)VlcgheterozygoteEarly adult2.46x10-5 
increased heart weight1 supporting datasetHtr1btm1.1(KOMP)VlcgheterozygoteEarly adult1.1x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Htr1btm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Htr1btm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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