Hoxa2 | homeobox A2

GeneMGI:96174Synonyms: Hox-1.11

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Nervous system Hearing/vestibular/ear Behavior/neurological Mortality/aging Craniofacial

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Hoxa2^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased prepulse inhibition	4 supporting datasets	Hoxa2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.05x10^-10
improved glucose tolerance	1 supporting dataset	Hoxa2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.82x10^-5
decreased respiratory quotient	1 supporting dataset	Hoxa2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	9.68x10^-6
abnormal auditory brainstem response	1 supporting dataset	Hoxa2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.67x10^-6
abnormal snout morphology	1 supporting dataset	Hoxa2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.03x10^-5
abnormal gait	1 supporting dataset	Hoxa2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	5.35x10^-5
decreased circulating creatinine level	1 supporting dataset	Hoxa2^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	7.7x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hoxa2.

Associated images

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Histopathology

There is no histopathology data found for Hoxa2.

IMPC related publications

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External links

No external links available for Hoxa2.

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*Hoxa2^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Hoxa2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Hoxa2^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Hoxa2^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Hoxa2^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Hoxa2^{tm86337(L1L2_gt1_Del_LacZ)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Hoxa2^{tm86337(pL1L2_frt15_BetactinBSD_frt14_neo_Rox)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes