Hspa5 | heat shock protein 5

GeneMGI:95835Synonyms: D2Wsu141e, D2Wsu17e, +8 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Mortality/aging Cardiovascular system

15 No significant impact

5 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:48Adult tissues
25Embryo tissues

Phenotypes

embryonic lethality prior to tooth bud stage1 supporting datasetHspa5tm1.1(KOMP)VlcghomozygoteE12.5N/A * 
increased heart weight1 supporting datasetHspa5tm1.1(KOMP)VlcgheterozygoteEarly adult3.81x10-7 
increased circulating cholesterol level1 supporting datasetHspa5tm1.1(KOMP)VlcgheterozygoteEarly adult7.12x10-6 
preweaning lethality, complete penetrance1 supporting datasetHspa5tm1.1(KOMP)VlcghomozygoteEarly adultN/A * 
embryonic lethality prior to organogenesis1 supporting datasetHspa5tm1.1(KOMP)VlcghomozygoteE9.5N/A * 
decreased circulating chloride level1 supporting datasetHspa5tm1.1(KOMP)VlcgheterozygoteEarly adult6.22x10-6 
increased circulating HDL cholesterol level1 supporting datasetHspa5tm1.1(KOMP)VlcgheterozygoteEarly adult7.65x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Hspa5tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Hspa5tm1.1(KOMP)VlcgReporter-tagged deletion allele (post Cre, with no selection cassette)mouse

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